Researchers are attempting to use artificial intelligence to predict the next pandemic.

Artificial intelligence could detect animal viruses that have the potential to cause pandemics in humans, according to new research. 

Most emerging infectious diseases of humans (like COVID-19) are zoonotic – caused by viruses originating from other animal species.

New research suggests that machine learning (a type of artificial intelligence) using viral genomes may predict the likelihood that any animal-infecting virus will infect humans, given biologically relevant exposure.

Identifying zoonotic diseases prior to emergence is a major challenge because only a small minority of the estimated 1.67 million animal viruses are able to infect humans. 

To develop machine learning models using viral genome sequences, the researchers first compiled a dataset of 861 virus species from 36 families. 

They then built machine learning models, which assigned a probability of human infection based on virus taxonomy and/or relatedness to known human-infecting viruses. 

The researchers then applied the best-performing model to analyse patterns in the predicted zoonotic potential of additional virus genomes sampled from a range of species.

They found that viral genomes may have generalisable features that are independent of virus taxonomic relationships and may preadapt viruses to infect humans. 

They were able to develop machine learning models capable of identifying candidate zoonoses using viral genomes. 

These models have limitations, as computer models are only a preliminary step of identifying zoonotic viruses with potential to infect humans. Viruses flagged by the models will require confirmatory laboratory testing before pursuing major additional research investments. 

Further, while these models predict whether viruses might be able to infect humans, the ability to infect is just one part of broader zoonotic risk, which is also influenced by the virus’ virulence in humans, ability to transmit between humans, and the ecological conditions at the time of human exposure.

“Our findings show that the zoonotic potential of viruses can be inferred to a surprisingly large extent from their genome sequence,” say the authors of a new report published by PLOS.

“By highlighting viruses with the greatest potential to become zoonotic, genome-based ranking allows further ecological and virological characterisation to be targeted more effectively.”

“A genomic sequence is typically the first, and often only, information we have on newly-discovered viruses, and the more information we can extract from it, the sooner we might identify the virus’ origins and the zoonotic risk it may pose,” says researcher Simon Babayan.

“As more viruses are characterised, the more effective our machine learning models will become at identifying the rare viruses that ought to be closely monitored and prioritised for preemptive vaccine development.”